PKRRATING - AN OVERVIEW

The activated enzyme then phosphorylates its major substrate, the translational initiation issue eIF2α. The resulting translational arrest blocks viral replication. PKR belongs to a conserved household of 4 protein kinases (PKR, PERK, GCN2, HRI) that every one phosphorylate eIF2α in reaction to different stimuli12, triggering the built-in pressur